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Ipak, kada dođe do razvoja bolesti (upala pluća, astma, bronhitis, HOBP, cistična fibroza) nivo glutationa u ćelijama drastično opada i potrebna je nadonada putem suplemenata Dijabetes Dijabetičari imaju za čak 63% niže nivoe glutationa u tkivima, čime se povećava rizik sa nastanak komplikacija Bolesti jetre Glutationa ima najviše u jetri, tako da sve ono što jetri šteti dovodi do smanjenja glutationa u hepatocitima (ćelijama jetre)