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In addition, histopathological and immunohistochemical assessments were performed to evaluate tissue architecture, inflammatory infiltration, collagen deposition, and the expression of VEGF, eNOS, IL-6, and caspase-3

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In contrast, in a model of skin carcinogenesis, GPx-1-overexpressing mice have an accelerated pattern of lesion development, have more tumors per mouse, and have tumors with increased growth rates, as measured by BrdU labeling (238)