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In addition, the pain information transmission caused by the original peripheral nerve injury is out of balance when the expression of opioid receptors is downregulated in DRGs, resulting in the inability of endogenous opioid peptides to act on the receptor and leading to peripheral sensitization, which is also an important mechanism for the formation of morphine tolerance that seems to indicate that subcutaneous morphine injection in NP patients is difficult to modify to achieve better efficacy [77,81,105,108,128]

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Limitations and Clinical Considerations Although results are promising, several important considerations remain: Cagrilintide Powder ： Individual responses vary significantly Gastrointestinal side effects are relatively common in incretin-based therapies Long-term safety beyond clinical trial durations is still under evaluation Weight regain after discontinuation remains a concern, as with most anti-obesity therapies Therefore, results should be interpreted within the controlled context of clinical trials rather than as guaranteed outcomes